Unlocking Innovation with High-Throughput Experimentation (HTE)
Imagine accelerating your entire R&D pipeline—what used to take months now happens in days. That’s the power of High-Throughput Experimentation (HTE).
HTE is transforming scientific research by enabling the parallel execution of hundreds of experiments, dramatically speeding up discovery and development. This approach is already making a significant impact across industries such as pharmaceuticals, agrochemicals, fragrances, energy & sustainability, and material science.
By combining automation and miniaturization, HTE allows researchers to conduct hundreds of experiments in a fraction of the time required by traditional methods. When integrated with data science and machine learning, HTE becomes a powerful tool for systematically exploring chemical space and driving innovation through data-driven decision-making.
Key Benefits of HTE
Time Efficiency: Simultaneous execution of experiments significantly shortens development timelines.
Cost Reduction: Miniaturized, parallel experiments reduce material usage and labour costs.
Reproducibility: Robotic automation ensures consistent conditions, improving data reliability.
Sustainability: Fewer resources are needed thanks to miniaturized, automated workflows.
Innovation: Enables broader exploration of parameters, leading to novel discoveries and rich datasets.
Application Areas
High-Throughput Experimentation (HTE) is a versatile platform that supports the entire pharmaceutical development lifecycle. From early-stage drug discovery to process optimization and regulatory filing, HTE enables rapid, data-rich experimentation that drives informed decision-making at every step.
Drug Discovery
HTE accelerates drug discovery by streamlining Design-Make-Test-Analyze (DMTA) cycles. Through rapid screening of reaction conditions across diverse substrates and enabling efficient library synthesis, it facilitates the faster development of novel drug candidates.
Early process enabling
HTE provides systematic screening of reactions, solubility, and solid forms. This helps identify and resolve potential bottlenecks, ensuring smoother technology transfer for both GMP and non-GMP manufacturing environments.
Route Scouting
In route scouting or route design, HTE can be used to screen reactions on key synthetic steps, helping teams rapidly validate or eliminate potential synthetic routes. This speeds up decision-making and focuses resources on the most viable pathways. This allows researchers to identify synthetic pathways that are not only efficient and cost effective but also the most sustainable.
Process design
HTE empowers data-driven optimization to develop robust, scalable, and environmentally conscious commercial processes. This includes refining both reaction conditions and isolation strategies by generating the required fundamental data to design the most optimal and sustainable processes for commercial manufacture.
Material Science
HTE plays a transformative role in material science by enabling rapid screening and optimization of material properties across a wide range of compositions and processing conditions.
Artificial intelligence
By generating high-quality, reproducible datasets aligned with FAIR principles (Findable, Accessible, Interoperable, and Reusable), HTE enables the creation of large, structured datasets that can be used to train machine learning models for predictive chemical discovery.
Services and Offerings
HTE services can be offered as part of a fully integrated process chemistry solution or as standalone services, depending on project needs. These services include:
Reaction Optimization
- Screening for homogeneous and heterogeneous catalysis, including photochemistry, electrochemistry, biocatalysis, and air/pressure-sensitive reactions.
- Categorical variable optimization across all reaction types augmented with computationally derived molecular property databases for advanced data-science applications.
- Design of Experiments, executed within high-throughput workflows, leveraging statistical and quasi-sampling methods combined with Bayesian optimisation to enable efficient optimisation of continuous variables.
Material Science
- Thermodynamic solubility measurements enhanced with data-driven regression modelling.
- Achiral and chiral salt resolution for identifying crystalline intermediates and purification strategies.
- Polymorph and morphology screening to ensure optimal performance, manufacturability, and regulatory compliance.
Purification
- Liquid-liquid extraction screening for purification and process intensification.
- Absorbent and scavenger screening for impurity and metal removal.
- Solvent crystallization with impurity purge to supplement high-throughput salt screening.
How Do We Differentiate?
We differentiate ourselves through a unique combination of advanced technology, data-driven methodologies, and deep scientific expertise. Our state-of-the-art robotic laboratory operates 24/7 with minimal human intervention, ensuring maximum productivity, consistency, and reproducibility.
This high level of automation enables rapid, data-rich experimentation, delivering deeper insights and faster decision-making. We further enhance our capabilities by integrating machine learning into expansive datasets, uncovering patterns and predictive insights that traditional methods often miss.
At the core of our success is a team of scientists with decades of experience in HTE, synthesis, process chemistry, and catalysis—bringing high-quality outcomes and innovative solutions to every project.
By merging cutting-edge tools with expert knowledge, we redefine what’s possible in High-Throughput Experimentation and drive innovation across industries.
Ready to transform your R&D strategy?
Let’s talk about how HTE can accelerate your innovation.
