Technology &
Engineering Sciences

Imagine accelerating your entire R&D pipeline—what used to take months now happens in days. That’s the power of High-Throughput Experimentation (HTE).

Crystallization is a critical step in drug substance manufacturing, influencing key process outcomes such as impurity control, yield, throughput, filtration and drying performance, solid form control, and regulatory compliance (e.g., particle size). It also plays a vital role in downstream processing, affecting properties such as flowability, bulk density, and dissolution behaviour.

We collaborate closely with our Biocatalysis group in China, an industry-leading R&D team specializing in the development of Enzyme Manufacturing Technology, to develop optimal solutions for clients’ processes.

Asymchem’s sandwich site is expanding capabilities to support our renowned expertise in photo and electro chemical transformations!

One of our core strengths is integrating engineering principles into our project teams and embedding best practices into our workflows. The Sandwich team has a strong history of applying these principles to design optimized synthetic routes, develop robust manufacturing processes, de-risk scale-up, and support technology transfer and regulatory submissions.

The Asymchem Sandwich group has extensive experience in developing continuous processes and believe we have the perfect combination of expertise that leverages our knowledge in route scouting, process development and scale-up to build and develop end-to-end continuous flow processes. We empower our chemists to use flow chemistry as another facet to the process development toolbox giving access to new design spaces for developing more efficient scalable and sustainable processes.

API manufacturing frequently utilizes high-pressure chemistry, such as reactions involving gases as reagents, like catalytic hydrogenation. At Asymchem Sandwich, we can leverage the Asymchem groups' dedicated research, which has access to over 1000 different catalysts, allowing us to develop the optimal solution for your chemistry.

At Asymchem Sandwich, we conduct thorough and detailed hazard assessments at every stage of process development. Our highly experienced team performs comprehensive hazard evaluations during the development phase and prior to scale-up, ensuring the safe operation of the process. In our dedicated process laboratory, we conduct calorimetry and thermal screening to assess the thermal hazards of a process, along with specialized testing for vent sizing when necessary. Our state-of-the-art facility is fully equipped to carry out complete hazard assessments for any given process.