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Route & Process Enabling Pressure Chemistry

Process R&D Route & Process Enabling

Route & Process Enabling

At Asymchem, we understand that today's R&D challenges don't have to become tomorrow's manufacturing problems. That's why we are always looking ahead to create the safest, most sustainable, and efficient processes possible. Our Process Enabling workflow offers a cost-effective strategy to mitigate risks during the early manufacturing stages of your target compound.

Route & Process Enabling

01

Review Process

Engage in a detailed discussion with the client to listen and clarify the scope.
Identify the key drivers specific to the client and the target compound that will influence decision-making.
Understand the project's relevant history to ensure that all learnings are properly captured.
A process review is conducted to identify potential vulnerabilities at scale, allowing prioritization of unit operations at risk of issues on scale-up.
Sustainability metrics are initially collected as part of a benchmarking exercise.

02

Laboratory Execution

Modern process chemistry lab equipment, operated by highly experienced staff, enables the swift exploration of proposed process improvements.
The reaction engineering team is available to address potential scale-up risks as early as possible.
Industry-leading High-Throughput Experimentation (HTE) can rapidly evaluate chemical space to identify optimum, reaction, extraction and isolation conditions using state-of-the-art automated technology.
Integrated Process Safety specialists provide guidance and support ensuring safety is an inherent factor in process enabling.
Process Reviews and Process Brainstorms are conducted during lab execution, fostering new ideas and generating process improvements.
If required analytical method development can be performed in conjunction with process enabling as a comprehensive strategy to mitigate risks to quality.

03

Tech Transfer & Review

Our fully integrated Sandwich R&D and manufacturing site enables seamless Tech Transfer from lab to manufacturing through established processes and working relationships.
After Action Reviews are conducted following each deliverable. These reviews, which can be part of smaller deliveries or pilot plant operations
depending on the scope of the work, are documented in a detailed development report.
Sustainability metrics are collected as a key deliverable, with a focus on reducing PMI, cycle-time, LCA, and costs.

Output: A stage and scale appropriate manufacturing process.

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Process Validation Readiness

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Structure Elucidation

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Control Strategy and Regulatory Support

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