Popular search terms:

Route & Process Enabling Pressure Chemistry

Process R&D Structure Elucidation

Structure Elucidation

Asymchem's Structure Elucidation team plays a crucial role in our comprehensive analytical services, ensuring precise identification and characterization of complex molecules. With over 20 years of experience in problem-solving and structure elucidation within the pharmaceutical industry, our team is well-versed in a wide range of spectroscopy and spectrometry applications.

Structure Elucidation

Key Aspects of Asymchem’s Structure Elucidation Capabilities

Expertise in the elucidation of complex molecules of unknown, related and unrelated compounds, including organic compounds, chiral intermediates and novel chemical entities
Knowledge and experience in the analysis of extractables and leachables
Determination of the composition of counterfeit medicines
Regulatory compliance and supporting regulatory filings
Spectroscopic databasing and the use of predictive computational tools

Our integration of advanced instrumentation and methodology allow Asymchem to quickly enable the precise determination of molecular structures and the identification of impurities.

Nuclear Magnetic Resonance (NMR)

Instrumentation

Bruker 400MHz Avance Neo Spectrometer

Capabilities

1D NMR – 1H / 13C / 19F / 31P / 35Cl
2D NMR homo- and hetero- nuclear experiments (such as COSY, TOCSY, HSQC, HMBC, ROESY)
Variable temperature NMR
QNMR
GMP NMR analysis

Application Examples

Full structure confirmation using a suite of 1D and 2D NMR experiments leading to confident assignment of structure for unknowns, impurities, degradants and reference materials
Quantitative analysis of impurities and solvents in samples
Variable temperature analysis of molecules to determine form interconversion and kinetics
GMP analysis available for material release and regulatory support

Mass Spectrometry (MS)

Instrumentation

Agilent 6550 QToF mass spectrometer with Agilent 1290 infinity LC
Thermo Orbitrap Exploris 120 with Thermo Flex LC

Capabilities and Application

LC-MS for separation and detection of complex mixtures
High resolution accurate mass analysis for confident formula determination
Tandem mass spectrometry (MS/MS) to aid in structure elucidation of unknowns
Quantitation and trace analysis
Electrospray, APCI and APPI ionisation modes
GMP LC-MS analysis

FTIR

Instrumentation

Thermo Nicolet is10 FT-IR with Golden Gate ™ ATR smart accessory

Capabilities and Application

Provision of FT-IR for reference materials
FT-IR spectra assignments
Functional group confirmation

Related Recommendations

Analytical Method Development & Validation

Analytical Method Development & Validation

Route & Process Enabling

Route & Process Enabling

Route Scouting & Design

Route Scouting & Design

Data Centric Process Design

Data Centric Process Design

Process Validation Readiness

Process Validation Readiness

Control Strategy and Regulatory Support

Control Strategy and Regulatory Support

You might also like

Asymchem is now open in the UK with an integrated small molecule R&D and GMP manufacturing facility in Sandwich, Kent. We provide end-to-end development and manufacturing solutions, powered by data-rich experimentation and digital tools.

We power our operations with a renewable biomass plant, providing clean energy onsite and sending surplus electricity to local homes. Sustainable forestry practices actively offset carbon, while lab and pilot plant waste is managed responsibly, incinerated waste generates electricity, and solvents are fully recycled as fuel.

As a global CRDMO leader, we accelerate lab-to-patient drug journeys, partnering with pioneers to deliver life-changing therapies. Whether in R&D, manufacturing or strategy, your expertise drives impact. We offer mentorship, cutting-edge projects and a collaborative culture. Explore roles—let’s co-create healthcare breakthroughs.

Cookie Settings

When you visit any website, it may store or retrieve information on your browser, mostly in the form of cookies. This information might be about you or your device and is mostly used to make the site work as you expect it to. The information does not usually directly identify you, but it can give you a more personalized web experience. Because we respect your right to privacy, you can choose not to allow some types of cookies. Click on the different category headings to find out more and change our default settings. However, blocking some types of cookies may impact your experience of the site. You may change your consent to Cookies at any time through the “Change your consent” button in the Cookie Policy

Required Cookies

These Cookies are essential for the website to function and cannot be switched off in our system. They enable basic functions like page navigation and access to secure areas of the website. These Cookies do not store any personally identifiable information. You can set your browser to block or alert you about these Cookies, but some parts of the site will not then work.

Analytical Cookies

These Cookies allow us to conduct an internal analysis to understand how our website performs, and how visitors interact with our website. Analytical Cookies may count visits and traffic sources and track performance and technical issues, all of which will help us to improve the website and to provide better, more relevant information to our users. All information collected through Analytical Cookies is aggregated, Non-Personal Information.

CONFIRM MY CHOICE