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Route & Process Enabling Pressure Chemistry

Process R&D Route Scouting & Design

Route Scouting & Design

Our Route Scouting services are designed to identify and demonstrate the most efficient and cost-effective synthetic routes for your target compounds. By leveraging our extensive expertise and advanced technologies, we ensure that your route design is optimised for scalability, sustainability, and regulatory compliance.

Route Scouting & Design

01

Scope & Drivers

Detailed discussion with the client to listen and clarify the scope.
Understand key drivers specific to the client and the target compound that will drive decision making in terms of route prioritization.

02

Idea Generation

Thorough retrosynthetic analysis executed by a vastly experienced team of process chemists.
Advanced flow chemistry capabilities enable access to chemical space not open to batch processes.
Established biocatalysis expertise provides a green technology to install chirality into target compounds.
Utilization of the wider Asymchem network to identify inexpensive and readily available raw materials/commodities as route starting points.
Route prioritization tool which ranks route options based on ‘chance of success’ and ‘value’.

03

Laboratory Execution

Modern process chemistry lab equipment in the hands of highly experienced lab staff ensures the rapid exploration of new route ideas.
Industry leading HTE to rapidly assess if a proposed transformation is feasible via assessment of a broad set of reaction conditions utilizing state-of-the-art automated technology.
Salt & solid form screening enables the identification of solid intermediates that can be used as control points and/or regulatory starting materials (RSM).
Integrated Process Safety specialists provide guidance and support at all stages of route scouting to ensure safety is designed into the route from the start.

04

Critical Assessment

Reaction engineering team available to perform fit-for-purpose assessments of key transformations.
Process analytical technology (PAT) provides real time analytical data for key reactions.
Evolving impurity landscape and potential for PGI’s and nitrosamines in the new route(s) assessed in collaboration with ARD.
Detailed route comparison assessment in conjunction with the client to nominate the optimum synthetic route.

Output: The Optimum Synthetic Route For Commercial Manufacture

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